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CatSperbeta, a novel transmembrane protein in the CatSper channel complex.

Four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. We set out to identify proteins associating with CatSper that might help explain its unique role in spermatozoa. Using a transgenic approach, a CatSper1 complex was purified from mouse testis that contained heat shock protein 70-2, a testis-specific chaperone, and CatSperbeta, a novel protein with two putative transmembrane-spanning domains. Like the CatSper ion channel subunits, CatSperbeta was restricted to testis and localized to the principal piece of the sperm tail. CatSperbeta protein is absent in CatSper1(-/-) sperm, suggesting that it is required for trafficking or formation of a stable channel complex. CatSperbeta is the first identified auxiliary protein to the CatSper channel.

Pubmed ID: 17478420


  • Liu J
  • Xia J
  • Cho KH
  • Clapham DE
  • Ren D


The Journal of biological chemistry

Publication Data

June 29, 2007

Associated Grants


Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Calcium Channels
  • Cell Line
  • Female
  • HSP70 Heat-Shock Proteins
  • Humans
  • Kidney
  • Male
  • Membrane Proteins
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Molecular Sequence Data
  • Multiprotein Complexes
  • Patch-Clamp Techniques
  • Protein Transport
  • Sperm Tail