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Requirement of bic/microRNA-155 for normal immune function.

MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155-deficient CD4+ T cells identified a wide spectrum of microRNA-155-regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.

Pubmed ID: 17463290

Authors

  • Rodriguez A
  • Vigorito E
  • Clare S
  • Warren MV
  • Couttet P
  • Soond DR
  • van Dongen S
  • Grocock RJ
  • Das PP
  • Miska EA
  • Vetrie D
  • Okkenhaug K
  • Enright AJ
  • Dougan G
  • Turner M
  • Bradley A

Journal

Science (New York, N.Y.)

Publication Data

April 27, 2007

Associated Grants

  • Agency: Wellcome Trust, Id: 077187
  • Agency: Medical Research Council, Id: G117/424
  • Agency: Wellcome Trust, Id:

Mesh Terms

  • 3' Untranslated Regions
  • Animals
  • B-Lymphocytes
  • Cytokines
  • Dendritic Cells
  • Gene Expression Regulation
  • Gene Targeting
  • Homeostasis
  • Immune System
  • Immunoglobulin G
  • Lung
  • Lung Diseases
  • Lymphocyte Activation
  • Mice
  • MicroRNAs
  • Oligonucleotide Array Sequence Analysis
  • Proto-Oncogene Proteins c-maf
  • Salmonella Infections, Animal
  • T-Lymphocytes
  • Th1 Cells
  • Th2 Cells
  • Vaccination