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Regulation of the germinal center response by microRNA-155.

MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.

Pubmed ID: 17463289


  • Thai TH
  • Calado DP
  • Casola S
  • Ansel KM
  • Xiao C
  • Xue Y
  • Murphy A
  • Frendewey D
  • Valenzuela D
  • Kutok JL
  • Schmidt-Supprian M
  • Rajewsky N
  • Yancopoulos G
  • Rao A
  • Rajewsky K


Science (New York, N.Y.)

Publication Data

April 27, 2007

Associated Grants

  • Agency: NIAID NIH HHS, Id: AI064345

Mesh Terms

  • Animals
  • B-Lymphocytes
  • Cell Differentiation
  • Cells, Cultured
  • Cytokines
  • Germinal Center
  • Immunoglobulin G
  • Lymphocyte Activation
  • Lymphotoxin-alpha
  • Lymphotoxin-beta
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • MicroRNAs
  • Nitrophenols
  • Peyer's Patches
  • Phenylacetates
  • Somatic Hypermutation, Immunoglobulin
  • Spleen
  • T-Lymphocytes
  • Th1 Cells
  • Th2 Cells
  • Tumor Necrosis Factor-alpha