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A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis.

Science (New York, N.Y.) | Apr 27, 2007

Dynamin 1 is a neuron-specific guanosine triphosphatase thought to be critically required for the fission reaction of synaptic vesicle endocytosis. Unexpectedly, mice lacking dynamin 1 were able to form functional synapses, even though their postnatal viability was limited. However, during spontaneous network activity, branched, tubular plasma membrane invaginations accumulated, capped by clathrin-coated pits, in synapses of dynamin 1-knockout mice. Synaptic vesicle endocytosis was severely impaired during strong exogenous stimulation but resumed efficiently when the stimulus was terminated. Thus, dynamin 1-independent mechanisms can support limited synaptic vesicle endocytosis, but dynamin 1 is needed during high levels of neuronal activity.

Pubmed ID: 17463283 RIS Download

Mesh terms: Action Potentials | Animals | Cell Membrane | Clathrin-Coated Vesicles | Dynamin I | Dynamin II | Dynamin III | Electric Stimulation | Endocytosis | Excitatory Postsynaptic Potentials | Exocytosis | Inhibitory Postsynaptic Potentials | Mice | Mice, Knockout | Microscopy, Electron | Neurons | Patch-Clamp Techniques | Presynaptic Terminals | Synapses | Synaptic Transmission | Synaptic Vesicles

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Associated grants

  • Agency: NINDS NIH HHS, Id: R01 NS036942
  • Agency: NCRR NIH HHS, Id: RR-000592
  • Agency: NIDA NIH HHS, Id: P30 DA018343
  • Agency: NIDDK NIH HHS, Id: DK45735
  • Agency: NCI NIH HHS, Id: CA46128
  • Agency: NIDA NIH HHS, Id: DA018343
  • Agency: NINDS NIH HHS, Id: NS036942
  • Agency: NIDA NIH HHS, Id: DA17297
  • Agency: NINDS NIH HHS, Id: NS36251
  • Agency: Telethon, Id: D.061

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