• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


FANCI is a second monoubiquitinated member of the Fanconi anemia pathway.

Activation of the Fanconi anemia (FA) DNA damage-response pathway results in the monoubiquitination of FANCD2, which is regulated by the nuclear FA core ubiquitin ligase complex. A FANCD2 protein sequence-based homology search facilitated the discovery of FANCI, a second monoubiquitinated component of the FA pathway. Biallelic mutations in the gene coding for this protein were found in cells from four FA patients, including an FA-I reference cell line.

Pubmed ID: 17460694


  • Sims AE
  • Spiteri E
  • Sims RJ
  • Arita AG
  • Lach FP
  • Landers T
  • Wurm M
  • Freund M
  • Neveling K
  • Hanenberg H
  • Auerbach AD
  • Huang TT


Nature structural & molecular biology

Publication Data

June 5, 2007

Associated Grants

  • Agency: NIGMS NIH HHS, Id: R01 GM084244
  • Agency: NHLBI NIH HHS, Id: R37HL32987

Mesh Terms

  • Amino Acid Sequence
  • Base Sequence
  • Blotting, Western
  • Computational Biology
  • DNA Repair
  • Fanconi Anemia
  • Fanconi Anemia Complementation Group D2 Protein
  • Fanconi Anemia Complementation Group Proteins
  • HeLa Cells
  • Humans
  • Immunoprecipitation
  • Microscopy, Fluorescence
  • Molecular Sequence Data
  • Mutation
  • Sequence Analysis, DNA
  • Ubiquitination