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The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections.

Although it has been shown that mast cell-deficient mice have diminished innate immune responses against bacteria, the most important immunoprotective factors secreted from activated mast cells have not been identified. Mouse mast cell protease 6 is a tetramer-forming tryptase. This serine protease is abundant in the secretory granules and is exocytosed upon bacterial challenge. Here we have described the generation of a mast cell protease-6-null mouse. Our discovery that mice lacking this neutral protease cannot efficiently clear Klebsiella pneumoniae from their peritoneal cavities reveals an essential role for this serine protease, and presumably its human ortholog, in innate immunity.

Pubmed ID: 17456473

Authors

  • Thakurdas SM
  • Melicoff E
  • Sansores-Garcia L
  • Moreira DC
  • Petrova Y
  • Stevens RL
  • Adachi R

Journal

The Journal of biological chemistry

Publication Data

July 20, 2007

Associated Grants

  • Agency: NIAID NIH HHS, Id: AI-54950
  • Agency: NHLBI NIH HHS, Id: HL-36110
  • Agency: NCI NIH HHS, Id: P30CA16672

Mesh Terms

  • Animals
  • Interleukin-6
  • Klebsiella Infections
  • Klebsiella pneumoniae
  • Mast Cells
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Microscopy, Fluorescence
  • Peptide Hydrolases
  • Time Factors
  • Tryptases
  • Tumor Necrosis Factor-alpha