Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections.

http://www.ncbi.nlm.nih.gov/pubmed/17456473

Although it has been shown that mast cell-deficient mice have diminished innate immune responses against bacteria, the most important immunoprotective factors secreted from activated mast cells have not been identified. Mouse mast cell protease 6 is a tetramer-forming tryptase. This serine protease is abundant in the secretory granules and is exocytosed upon bacterial challenge. Here we have described the generation of a mast cell protease-6-null mouse. Our discovery that mice lacking this neutral protease cannot efficiently clear Klebsiella pneumoniae from their peritoneal cavities reveals an essential role for this serine protease, and presumably its human ortholog, in innate immunity.

Pubmed ID: 17456473 RIS Download

Mesh terms: Animals | Interleukin-6 | Klebsiella Infections | Klebsiella pneumoniae | Mast Cells | Mice | Mice, Inbred C57BL | Mice, Transgenic | Microscopy, Fluorescence | Peptide Hydrolases | Time Factors | Tryptases | Tumor Necrosis Factor-alpha

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIAID NIH HHS, Id: AI-54950
  • Agency: NHLBI NIH HHS, Id: HL-36110
  • Agency: NCI NIH HHS, Id: P30CA16672

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.