• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


A conditional mouse model of synovial sarcoma: insights into a myogenic origin.

Synovial sarcoma is an aggressive soft-tissue malignancy marked by a unique t(X;18) translocation leading to expression of a chimeric SYT-SSX fusion protein. We report here a mouse model of synovial sarcoma based on conditional expression of the human SYT-SSX2. Using this model, we have identified myoblasts as a potential source of synovial sarcoma. Remarkably, within the skeletal muscle lineage, while expression of the oncoprotein in immature myoblasts leads to induction of synovial sarcoma with 100% penetrance, its expression in more differentiated cells induces myopathy without tumor induction. We also show that early widespread expression of the fusion protein disrupts normal embryogenesis, causing lethality.

Pubmed ID: 17418413


  • Haldar M
  • Hancock JD
  • Coffin CM
  • Lessnick SL
  • Capecchi MR


Cancer cell

Publication Data

April 9, 2007

Associated Grants


Mesh Terms

  • Animals
  • Apoptosis
  • Cell Differentiation
  • Disease Models, Animal
  • Embryo, Mammalian
  • Female
  • Gene Expression Profiling
  • Genes, Lethal
  • Humans
  • Immunoenzyme Techniques
  • In Situ Nick-End Labeling
  • Integrases
  • Mice
  • Mice, Knockout
  • Microarray Analysis
  • Muscle, Skeletal
  • Muscular Diseases
  • Myoblasts, Skeletal
  • Myogenic Regulatory Factor 5
  • Oncogene Proteins, Fusion
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sarcoma, Synovial
  • Time Factors