Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Control of stress-dependent cardiac growth and gene expression by a microRNA.

Science (New York, N.Y.) | Apr 27, 2007

The heart responds to diverse forms of stress by hypertrophic growth accompanied by fibrosis and eventual diminution of contractility, which results from down-regulation of alpha-myosin heavy chain (alphaMHC) and up-regulation of betaMHC, the primary contractile proteins of the heart. We found that a cardiac-specific microRNA (miR-208) encoded by an intron of the alphaMHC gene is required for cardiomyocyte hypertrophy, fibrosis, and expression of betaMHC in response to stress and hypothyroidism. Thus, the alphaMHC gene, in addition to encoding a major cardiac contractile protein, regulates cardiac growth and gene expression in response to stress and hormonal signaling through miR-208.

Pubmed ID: 17379774 RIS Download

Mesh terms: Animals | Cardiac Myosins | Cardiomegaly | Fibrosis | Gene Deletion | Gene Expression Regulation | Heart | Heart Diseases | Hypothyroidism | Introns | Mediator Complex | Mice | Mice, Transgenic | MicroRNAs | Myocardial Contraction | Myocardium | Myocytes, Cardiac | Myosin Heavy Chains | Oligonucleotide Array Sequence Analysis | Rats | Signal Transduction | Stress, Physiological | Transcription Factors | Triiodothyronine | Up-Regulation | Ventricular Myosins

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants


Mouse Genome Informatics (Data, Gene Annotation)

OMIM (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.