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Microarray reveals complement components are regulated in the serum-deprived rat retinal ganglion cell line.

Molecular vision | 2007

Glaucoma is a progressive eye disease that leads to blindness due to loss of retinal ganglion cells (RGCs). There are difficulties in using primary cultures of purified RGC to study this pathophysiology. RGC-5, a transformed not RGC line, expresses several markers characteristic of the RGCs. The aim of this study was to generate a genome-wide gene expression of RGC-5 following serum deprivation and to identify candidate genes that may be involved in the signal transduction pathways.

Pubmed ID: 17356516 RIS Download

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Associated grants

  • Agency: NCRR NIH HHS, United States
    Id: P20 RR016481

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ImageQuant (tool)

RRID:SCR_014246

Software for automatic general image analysis. It provides fully automatic analysis of 1-D gels including lane creation, background subtraction, band detection, molecular weight calibration, quantity calibration, and normalization. Editing tools are provided for cropping, rotating, and filtering images.

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RGC-5 (tool)

RRID:CVCL_4059

Cell line RGC-5 is a Transformed cell line with a species of origin Mus musculus (Mouse)

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SD (tool)

RRID:RGD_70508

Rattus norvegicus with name SD from RGD.

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