Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse.

Catsper3 and Catsper4 are two recently identified testis-specific genes homologous to Catsper1 and Catsper2 that have been shown to play an essential role in sperm hyperactivated motility and male fertility in mice. Here we report that Catsper3 and Catsper4 knockout male mice are completely infertile due to a quick loss of motility and a lack of hyperactivated motility under capacitating conditions. Our data demonstrate that both CATSPER3 and CATSPER4 are required for hyperactivated sperm motility during capacitation and for male fertility. The present study also demands a revisit to the idiopathic male infertility patients who show normal sperm counts and normal initial motility for defects in sperm hyperactivated motility and for potential CATSPER gene mutations. The CATSPER channel also may be an excellent drug target for male contraceptives.

Pubmed ID: 17344468


  • Jin J
  • Jin N
  • Zheng H
  • Ro S
  • Tafolla D
  • Sanders KM
  • Yan W


Biology of reproduction

Publication Data

July 21, 2007

Associated Grants

  • Agency: NICHD NIH HHS, Id: HD050281

Mesh Terms

  • Animals
  • Calcium Channels
  • Fertility
  • Gene Expression Regulation
  • Genotype
  • Ion Channels
  • Male
  • Mice
  • Mice, Knockout
  • Seminal Plasma Proteins
  • Sperm Motility
  • Spermatozoa