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Dissociable intrinsic connectivity networks for salience processing and executive control.


Variations in neural circuitry, inherited or acquired, may underlie important individual differences in thought, feeling, and action patterns. Here, we used task-free connectivity analyses to isolate and characterize two distinct networks typically coactivated during functional MRI tasks. We identified a "salience network," anchored by dorsal anterior cingulate (dACC) and orbital frontoinsular cortices with robust connectivity to subcortical and limbic structures, and an "executive-control network" that links dorsolateral frontal and parietal neocortices. These intrinsic connectivity networks showed dissociable correlations with functions measured outside the scanner. Prescan anxiety ratings correlated with intrinsic functional connectivity of the dACC node of the salience network, but with no region in the executive-control network, whereas executive task performance correlated with lateral parietal nodes of the executive-control network, but with no region in the salience network. Our findings suggest that task-free analysis of intrinsic connectivity networks may help elucidate the neural architectures that support fundamental aspects of human behavior.

Pubmed ID: 17329432


  • Seeley WW
  • Menon V
  • Schatzberg AF
  • Keller J
  • Glover GH
  • Kenna H
  • Reiss AL
  • Greicius MD


The Journal of neuroscience : the official journal of the Society for Neuroscience

Publication Data

February 28, 2007

Associated Grants

  • Agency: NICHD NIH HHS, Id: HD047520
  • Agency: NIA NIH HHS, Id: K08 AG027086-01
  • Agency: NINDS NIH HHS, Id: K23 NS048302
  • Agency: NINDS NIH HHS, Id: K23 NS048302-03
  • Agency: NIMH NIH HHS, Id: MH019938
  • Agency: NIMH NIH HHS, Id: MH050604
  • Agency: NINDS NIH HHS, Id: NS048302
  • Agency: NCRR NIH HHS, Id: RR000070
  • Agency: NCRR NIH HHS, Id: RR009784

Mesh Terms

  • Adaptation, Physiological
  • Adult
  • Aged
  • Female
  • Gyrus Cinguli
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Memory
  • Middle Aged
  • Nerve Net
  • Prefrontal Cortex
  • Reference Values
  • Thinking