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Reversal of neurological defects in a mouse model of Rett syndrome.

Science (New York, N.Y.) | Feb 23, 2007

http://www.ncbi.nlm.nih.gov/pubmed/17289941

Rett syndrome is an autism spectrum disorder caused by mosaic expression of mutant copies of the X-linked MECP2 gene in neurons. However, neurons do not die, which suggests that this is not a neurodegenerative disorder. An important question for future therapeutic approaches to this and related disorders concerns phenotypic reversibility. Can viable but defective neurons be repaired, or is the damage done during development without normal MeCP2 irrevocable? Using a mouse model, we demonstrate robust phenotypic reversal, as activation of MeCP2 expression leads to striking loss of advanced neurological symptoms in both immature and mature adult animals.

Pubmed ID: 17289941 RIS Download

Mesh terms: Animals | Brain | Chimera | Disease Models, Animal | Female | Gene Expression Regulation | Gene Targeting | Long-Term Potentiation | Male | Methyl-CpG-Binding Protein 2 | Mice | Mice, Inbred C57BL | Neurons | Phenotype | Rett Syndrome | Synaptic Transmission | Tamoxifen | Transgenes

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Associated grants

  • Agency: Wellcome Trust, Id:

Mouse Genome Informatics (Data, Gene Annotation)

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