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NeuroTerrain--a client-server system for browsing 3D biomedical image data sets.

BMC bioinformatics | 2007

Three dimensional biomedical image sets are becoming ubiquitous, along with the canonical atlases providing the necessary spatial context for analysis. To make full use of these 3D image sets, one must be able to present views for 2D display, either surface renderings or 2D cross-sections through the data. Typical display software is limited to presentations along one of the three orthogonal anatomical axes (coronal, horizontal, or sagittal). However, data sets precisely oriented along the major axes are rare. To make fullest use of these datasets, one must reasonably match the atlas' orientation; this involves resampling the atlas in planes matched to the data set. Traditionally, this requires the atlas and browser reside on the user's desktop; unfortunately, in addition to being monolithic programs, these tools often require substantial local resources. In this article, we describe a network-capable, client-server framework to slice and visualize 3D atlases at off-axis angles, along with an open client architecture and development kit to support integration into complex data analysis environments.

Pubmed ID: 17280615 RIS Download

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Associated grants

  • Agency: NCRR NIH HHS, United States
    Id: RR043050-S2
  • Agency: NIMH NIH HHS, United States
    Id: P20 MH062009
  • Agency: NIMH NIH HHS, United States
    Id: P20 MH62009
  • Agency: NCRR NIH HHS, United States
    Id: RR08605-08S1
  • Agency: NCRR NIH HHS, United States
    Id: P41 RR008605

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Mouse Brain Library (tool)

RRID:SCR_001112

Collection of high resolution images and databases of brains from many genetically characterized strains of mice with aim to systematically map and characterize genes that modulate architecture of mammalian CNS. Includes detailed information on genomes of many strains of mice. Consists of images from approximately 800 brains and numerical data from just over 8000 mice. You can search MBL by strain, age, sex, body or brain weight. Images of slide collection are available at series of resolutions. Apple's QuickTime Plugin is required to view available MBL Movies.

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