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Differentiation of Parkinson's disease and progressive supranuclear palsy with magnetic resonance imaging: the first Brazilian experience.

BACKGROUND: The objective of this study is to differentiate PSP from Parkinson's disease through magnetic resonance imaging. METHODS: We included 14 consecutive patients with PD (9) or PSP (5). These measures included the third ventricle, midbrain diameter, quadrigeminal plate, brainstem volumetry, and interpeduncular angle. RESULTS: Patients with PSP presented enlargement of third ventricle (100% vs. 33%), lower midbrain diameter (mean 13.2 +/- 1.7 mm vs. 16.5 +/- 1.7 mm) and thinning of the quadrigeminal plate (mean 2.7 +/- 0.3 mm vs. 3.6 +/- 0.3 mm) in comparison with PD. CONCLUSIONS: Characteristic findings on MRI may help to differentiate PD from PSP.

Pubmed ID: 17275393


  • Barsottini OG
  • Ferraz HB
  • Maia AC
  • Silva CJ
  • Rocha AJ


Parkinsonism & related disorders

Publication Data

October 1, 2007

Associated Grants


Mesh Terms

  • Aged
  • Brain
  • Brazil
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Parkinson Disease
  • Supranuclear Palsy, Progressive