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All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility.

Mammalian spermatozoa become motile at ejaculation, but before they can fertilize the egg, they must acquire more thrust to penetrate the cumulus and zona pellucida. The forceful asymmetric motion of hyperactivated spermatozoa requires Ca2+ entry into the sperm tail by an alkalinization-activated voltage-sensitive Ca2+-selective current (ICatSper). Hyperactivation requires CatSper1 and CatSper2 putative ion channel genes, but the function of two other related genes (CatSper3 and CatSper4) is not known. Here we show that targeted disruption of murine CatSper3 or CatSper4 also abrogated ICatSper, sperm cell hyperactivated motility and male fertility but did not affect spermatogenesis or initial motility. Direct protein interactions among CatSpers, the sperm specificity of these proteins, and loss of ICatSper in each of the four CatSper-/- mice indicate that CatSpers are highly specialized flagellar proteins.

Pubmed ID: 17227845 RIS Download

Mesh terms: Animals | Calcium Channels | Fertility | Male | Mice | Molecular Sequence Data | Protein Isoforms | Sperm Motility

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Associated grants

  • Agency: NICHD NIH HHS, Id: R01 HD045339
  • Agency: NICHD NIH HHS, Id: R01 HD036022
  • Agency: NICHD NIH HHS, Id: HD045339
  • Agency: NICHD NIH HHS, Id: HD36022
  • Agency: PHS HHS, Id: U01 45857

Mouse Genome Informatics (Data, Gene Annotation)

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