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hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.

Complete sets of cloned protein-encoding open reading frames (ORFs), or ORFeomes, are essential tools for large-scale proteomics and systems biology studies. Here we describe human ORFeome version 3.1 (hORFeome v3.1), currently the largest publicly available resource of full-length human ORFs (available at ). Generated by Gateway recombinational cloning, this collection contains 12,212 ORFs, representing 10,214 human genes, and corresponds to a 51% expansion of the original hORFeome v1.1. An online human ORFeome database, hORFDB, was built and serves as the central repository for all cloned human ORFs (http://horfdb.dfci.harvard.edu). This expansion of the original ORFeome resource greatly increases the potential experimental search space for large-scale proteomics studies, which will lead to the generation of more comprehensive datasets.

Pubmed ID: 17207965


  • Lamesch P
  • Li N
  • Milstein S
  • Fan C
  • Hao T
  • Szabo G
  • Hu Z
  • Venkatesan K
  • Bethel G
  • Martin P
  • Rogers J
  • Lawlor S
  • McLaren S
  • Dricot A
  • Borick H
  • Cusick ME
  • Vandenhaute J
  • Dunham I
  • Hill DE
  • Vidal M



Publication Data

March 12, 2007

Associated Grants


Mesh Terms

  • Animals
  • Chromosomes, Human
  • Cloning, Molecular
  • DNA, Complementary
  • Databases, Nucleic Acid
  • Genetic Predisposition to Disease
  • Genome, Human
  • Humans
  • Internet
  • Open Reading Frames
  • Proteomics
  • Sequence Analysis, DNA