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Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis.

Arthritis and rheumatism | 2007

Imatinib mesylate is a clinically well-tolerated small molecule inhibitor that exerts selective, dual inhibition of the transforming growth factor beta (TGFbeta) and platelet-derived growth factor (PDGF) pathways. This study was undertaken to test the potential use of imatinib mesylate as an antifibrotic drug for the treatment of dermal fibrosis in systemic sclerosis (SSc).

Pubmed ID: 17195235 RIS Download

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AFFN-UBE2B-3B10 antibody, deposited by EU Program Affinomics EMBL MACF (antibody)

RRID:AB_2617991

This monoclonal targets Ubiquitin-conjugating enzyme E2 B

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