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The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens.

Nature immunology | Feb 23, 2007

http://www.ncbi.nlm.nih.gov/pubmed/17187069

The caspase-recruitment domain-containing adaptor protein CARD9 regulates the innate signaling responses to fungal infection. Here we show that CARD9 is required for innate immune responses against intracellular pathogens. We generated Card9(-/-) mice and found that CARD9-deficient macrophages had defects in activation of the kinases p38 and Jnk but not of transcription factor NF-kappaB after bacterial and viral infection. CARD9-deficient mice failed to clear infection and showed altered cytokine production after challenge with Listeria monocytogenes. In wild-type cells, we found CARD9 inducibly associated with both the intracellular 'biosensor' Nod2 and the serine-threonine kinase RICK. Our data demonstrate that CARD9 has a critical function in Nod2-mediated activation of p38 and Jnk in innate immune responses to intracellular pathogens.

Pubmed ID: 17187069 RIS Download

Mesh terms: Adaptor Proteins, Signal Transducing | Animals | CARD Signaling Adaptor Proteins | Cells, Cultured | Cytokines | Enzyme Activation | Gene Expression | Immunity, Innate | Intracellular Space | Ligands | Listeria monocytogenes | Macrophages | Mice | Mice, Inbred C57BL | Mice, Knockout | NF-kappa B | Nod2 Signaling Adaptor Protein | Protein Binding | Receptor-Interacting Protein Serine-Threonine Kinase 2 | Signal Transduction | p38 Mitogen-Activated Protein Kinases

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