Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis.

http://www.ncbi.nlm.nih.gov/pubmed/17182110

Interactions between PD-1 and its two differentially expressed ligands, PD-L1 and PD-L2, attenuate T cell activation and effector function. To determine the role of these molecules in autoimmune disease of the CNS, PD-1-/-, PD-L1-/- and PD-L2-/- mice were generated and immunized to induce experimental autoimmune encephalomyelitis (EAE). PD-1-/- and PD-L1-/- mice developed more severe EAE than wild type and PD-L2-/- mice. Consistent with this, PD-1-/- and PD-L1-/- cells produced elevated levels of the pro-inflammatory cytokines IFN-gamma, TNF, IL-6 and IL-17. These results demonstrate that interactions between PD-1/PD-L1, but not PD-1/PDL-2, are crucial in attenuating T cell responses in EAE.

Pubmed ID: 17182110 RIS Download

Mesh terms: Animals | Antigens, CD274 | Antigens, CD80 | Antigens, Differentiation | Encephalomyelitis, Autoimmune, Experimental | Glycoproteins | Humans | Interferon-gamma | Interleukin-17 | Interleukin-6 | Lymph Nodes | Lymphocyte Activation | Membrane Glycoproteins | Mice | Mice, Knockout | Mice, Transgenic | Myelin-Oligodendrocyte Glycoprotein | Peptide Fragments | Peptides | Programmed Cell Death 1 Ligand 2 Protein | Programmed Cell Death 1 Receptor | Severity of Illness Index | T-Lymphocytes | Tumor Necrosis Factor-alpha

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.