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Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus.

Nature cell biology | Jan 2, 2007

http://www.ncbi.nlm.nih.gov/pubmed/17173041

The function of the subnuclear structure the promyelocytic leukaemia (PML) body is unclear largely because of the functional heterogeneity of its constituents. Here, we provide the evidence for a direct link between PML, higher-order chromatin organization and gene regulation. We show that PML physically and functionally interacts with the matrix attachment region (MAR)-binding protein, special AT-rich sequence binding protein 1 (SATB1) to organize the major histocompatibility complex (MHC) class I locus into distinct higher-order chromatin-loop structures. Interferon gamma (IFNgamma) treatment and silencing of either SATB1 or PML dynamically alter chromatin architecture, thus affecting the expression profile of a subset of MHC class I genes. Our studies identify PML and SATB1 as a regulatory complex that governs transcription by orchestrating dynamic chromatin-loop architecture.

Pubmed ID: 17173041 RIS Download

Mesh terms: Cell Line | Cell Nucleus | Chromatin | Gene Expression Regulation | Genes, MHC Class I | Humans | Interferon-gamma | Leukemia, Promyelocytic, Acute | Matrix Attachment Region Binding Proteins | Matrix Attachment Regions | Models, Molecular | Protein Isoforms | RNA Interference | Transcription, Genetic | Transfection

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Associated grants

  • Agency: Wellcome Trust, Id:

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