We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation.

Immunity | Dec 18, 2006

Nedd4 family interacting protein-1 (Ndfip1) is a protein whose only known function is that it binds Nedd4, a HECT-type E3 ubiquitin ligase. Here we show that mice lacking Ndfip1 developed severe inflammation of the skin and lung and died prematurely. This condition was due to a defect in Ndfip1(-/-) T cells. Ndfip1(-/-) T cells were activated, and they proliferated and adopted a T helper 2 (Th2) phenotype more readily than did their Ndfip1(+/+) counterparts. This phenotype resembled that of Itchy mutant mice, suggesting that Ndfip1 might affect the function of Itch, an E3 ubiquitin ligase. We show that T cell activation promoted both Ndfip1 expression and its association with Itch. In the absence of Ndfip1, JunB half-life was prolonged after T cell activation. Thus, in the absence of Ndfip1, Itch is inactive and JunB accumulates. As a result, T cells produce Th2 cytokines and promote Th2-mediated inflammatory disease.

Pubmed ID: 17137798 RIS Download

Mesh terms: Animals | Blotting, Western | Carrier Proteins | Cytokines | Flow Cytometry | Inflammation | Lymphocyte Activation | Membrane Proteins | Mice | Proto-Oncogene Proteins c-jun | Reverse Transcriptase Polymerase Chain Reaction | T-Lymphocytes | Th2 Cells | Ubiquitin-Protein Ligases

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIAID NIH HHS, Id: AI-52225
  • Agency: NIDDK NIH HHS, Id: P50 DK052617-100007
  • Agency: NIDDK NIH HHS, Id: P50 DK052617
  • Agency: NIAID NIH HHS, Id: R01 AI052225
  • Agency: NIDDK NIH HHS, Id: P50 DK52617
  • Agency: NHLBI NIH HHS, Id: R01 HL105834
  • Agency: NIAID NIH HHS, Id: AI-22295
  • Agency: NIAID NIH HHS, Id: P01 AI022295

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.