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Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses.

Nature immunology | Jan 20, 2007

http://www.ncbi.nlm.nih.gov/pubmed/17115060

HPK1 is a Ste20-related serine-threonine kinase that inducibly associates with the adaptors SLP-76 and Gads after T cell receptor (TCR) signaling. Here, HPK1 deficiency resulted in enhanced TCR-induced phosphorylation of SLP-76, phospholipase C-gamma1 and the kinase Erk, more-persistent calcium flux, and increased production of cytokines and antigen-specific antibodies. Furthermore, HPK1-deficient mice were more susceptible to experimental autoimmune encephalomyelitis. Although the interaction between SLP-76 and Gads was unaffected, the inducible association of SLP-76 with 14-3-3tau (a phosphorylated serine-binding protein and negative regulator of TCR signaling) was reduced in HPK1-deficient T cells after TCR stimulation. HPK1 phosphorylated SLP-76 and induced the interaction of SLP-76 with 14-3-3tau. Our results indicate that HPK1 negatively regulates TCR signaling and T cell-mediated immune responses.

Pubmed ID: 17115060 RIS Download

Mesh terms: Adaptor Proteins, Signal Transducing | Animals | Cells, Cultured | Down-Regulation | Immunity, Cellular | Mice | Mitogen-Activated Protein Kinase 3 | Phosphoproteins | Protein-Serine-Threonine Kinases | Receptors, Antigen, T-Cell | Signal Transduction | T-Lymphocytes

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Associated grants

  • Agency: NIAID NIH HHS, Id: R01-AI066895
  • Agency: NIAID NIH HHS, Id: R01-AI42532
  • Agency: NCI NIH HHS, Id: R01-CA87076
  • Agency: NIAID NIH HHS, Id: T32-AI07495

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