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MACiE (Mechanism, Annotation and Classification in Enzymes): novel tools for searching catalytic mechanisms.

MACiE (Mechanism, Annotation and Classification in Enzymes) is a database of enzyme reaction mechanisms, and is publicly available as a web-based data resource. This paper presents the first release of a web-based search tool to explore enzyme reaction mechanisms in MACiE. We also present Version 2 of MACiE, which doubles the dataset available (from Version 1). MACiE can be accessed from

Pubmed ID: 17082206


  • Holliday GL
  • Almonacid DE
  • Bartlett GJ
  • O'Boyle NM
  • Torrance JW
  • Murray-Rust P
  • Mitchell JB
  • Thornton JM


Nucleic acids research

Publication Data

January 4, 2007

Associated Grants

  • Agency: Biotechnology and Biological Sciences Research Council, Id: BB/C51320X/1
  • Agency: Wellcome Trust, Id:

Mesh Terms

  • Catalysis
  • Databases, Protein
  • Enzymes
  • Internet
  • Protein Conformation
  • Sequence Homology, Amino Acid
  • Software
  • User-Computer Interface