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DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases.

Genes & development | Nov 1, 2006

http://www.ncbi.nlm.nih.gov/pubmed/17079684

Cullins assemble the largest family of ubiquitin ligases by binding with ROC1 and various substrate receptors. CUL4 function is linked with many cellular processes, but its substrate-recruiting mechanism remains elusive. We identified a protein motif, the DWD box (DDB1-binding WD40 protein), and demonstrated the binding of 15 DWD proteins with DDB1-CUL4A. We provide evidence supporting the critical function of the DWD box and DDB1's role as the linker mediating DWD protein association with CUL4A. A database search predicts that about one-third of WD40 proteins, 90 in humans, contain the DWD box, suggesting a potentially large number of DWD-DDB1-CUL4-ROC1 E3 ligases.

Pubmed ID: 17079684 RIS Download

Mesh terms: Amino Acid Motifs | Amino Acid Sequence | Carrier Proteins | Conserved Sequence | Cullin Proteins | DNA-Binding Proteins | HeLa Cells | Humans | Molecular Sequence Data | Ubiquitin-Protein Ligases

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Associated grants

  • Agency: NIGMS NIH HHS, Id: GM067113

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