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CellProfiler: image analysis software for identifying and quantifying cell phenotypes.

Genome biology | Jan 18, 2006

http://www.ncbi.nlm.nih.gov/pubmed/17076895

Biologists can now prepare and image thousands of samples per day using automation, enabling chemical screens and functional genomics (for example, using RNA interference). Here we describe the first free, open-source system designed for flexible, high-throughput cell image analysis, CellProfiler. CellProfiler can address a variety of biological questions quantitatively, including standard assays (for example, cell count, size, per-cell protein levels) and complex morphological assays (for example, cell/organelle shape or subcellular patterns of DNA or protein staining).

Pubmed ID: 17076895 RIS Download

Mesh terms: Dose-Response Relationship, Drug | Gene Expression Profiling | Image Processing, Computer-Assisted | Models, Genetic | Mutation | Phenotype | Reproducibility of Results | Software

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