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Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report.

http://www.ncbi.nlm.nih.gov/pubmed/17074942

OBJECTIVE: This report describes the participants and compares the acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. METHOD: A broadly representative adult outpatient sample with nonpsychotic major depressive disorder received one (N=3,671) to four (N=123) successive acute treatment steps. Those not achieving remission with or unable to tolerate a treatment step were encouraged to move to the next step. Those with an acceptable benefit, preferably symptom remission, from any particular step could enter a 12-month naturalistic follow-up phase. A score of or=11 (HRSD(17)>or=14) defined relapse. RESULTS: The QIDS-SR(16) remission rates were 36.8%, 30.6%, 13.7%, and 13.0% for the first, second, third, and fourth acute treatment steps, respectively. The overall cumulative remission rate was 67%. Overall, those who required more treatment steps had higher relapse rates during the naturalistic follow-up phase. In addition, lower relapse rates were found among participants who were in remission at follow-up entry than for those who were not after the first three treatment steps. CONCLUSIONS: When more treatment steps are required, lower acute remission rates (especially in the third and fourth treatment steps) and higher relapse rates during the follow-up phase are to be expected. Studies to identify the best multistep treatment sequences for individual patients and the development of more broadly effective treatments are needed.

Pubmed ID: 17074942 RIS Download

Mesh terms: Adolescent | Adult | Aged | Ambulatory Care | Antidepressive Agents | Clinical Protocols | Cognitive Therapy | Combined Modality Therapy | Depressive Disorder, Major | Drug Therapy, Combination | Female | Follow-Up Studies | Humans | Male | Middle Aged | Personality Inventory | Psychiatric Status Rating Scales | Questionnaires | Secondary Prevention | Treatment Outcome