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Next-generation optical technologies for illuminating genetically targeted brain circuits.

Emerging technologies from optics, genetics, and bioengineering are being combined for studies of intact neural circuits. The rapid progression of such interdisciplinary "optogenetic" approaches has expanded capabilities for optical imaging and genetic targeting of specific cell types. Here we explore key recent advances that unite optical and genetic approaches, focusing on promising techniques that either allow novel studies of neural dynamics and behavior or provide fresh perspectives on classic model systems.

Pubmed ID: 17035522

Authors

  • Deisseroth K
  • Feng G
  • Majewska AK
  • Miesenböck G
  • Ting A
  • Schnitzer MJ

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience

Publication Data

October 11, 2006

Associated Grants

  • Agency: NINDS NIH HHS, Id: R01 NS050533
  • Agency: NINDS NIH HHS, Id: R01 NS050533-01
  • Agency: NIDA NIH HHS, Id: R21 DA017895
  • Agency: NIDA NIH HHS, Id: R21 DA017895-01
  • Agency: NIDCD NIH HHS, Id: R21 DC007902
  • Agency: NIDCD NIH HHS, Id: R21 DC007902-01

Mesh Terms

  • Animals
  • Brain
  • Gene Targeting
  • Humans
  • Microscopy, Fluorescence
  • Nerve Net
  • Neural Pathways
  • Optics and Photonics