We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator.

Cell | Aug 10, 1990

Spontaneous intestinal and intra-abdominal bleeding was observed in a high percentage of newborn transgenic mice carrying the murine urokinase-type plasminogen activator (uPA) gene linked to the albumin enhancer/promoter. These hemorrhagic events were directly related to transgene expression in the liver and the development of high plasma uPA levels. Two lines were established from surviving founder mice that displayed multigenerational transmission of the bleeding phenotype. Fatal hemorrhaging developed between 3 and 84 hr after birth in about half of the transgenic offspring of these lines; transgenic pups that did not bleed nevertheless passed the phenotype to their young. The phenotypic variability could not be explained by differences in transgene expression. All transgenic neonates were severely hypofibrinogenemic and displayed loss of clotting function that extended beyond the risk period for bleeding. These mice provide a means of studying the pathophysiology of plasminogen hyperactivation and evaluating therapeutic protocols designed to prevent bleeding.

Pubmed ID: 1696178 RIS Download

Mesh terms: Animals | Base Sequence | Blotting, Northern | Fibrinogen | Gastrointestinal Hemorrhage | Gene Expression | Growth Hormone | Humans | Liver | Mice | Mice, Transgenic | Molecular Sequence Data | Nucleic Acid Hybridization | Oligonucleotide Probes | Phenotype | Plasminogen Activators | Platelet Count | Protein Precursors | RNA | RNA, Messenger | Restriction Mapping | Urokinase-Type Plasminogen Activator

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.