Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Cutting edge: TREM-2 attenuates macrophage activation.

The triggering receptor expressed on myeloid cells 2 (TREM-2) delivers intracellular signals through the adaptor DAP12 to regulate myeloid cell function both within and outside the immune system. The role of TREM-2 in immunity has been obscured by the failure to detect expression of the TREM-2 protein in vivo. In this study, we show that TREM-2 is expressed on macrophages infiltrating the tissues from the circulation and that alternative activation with IL-4 can induce TREM-2. TREM-2 expression is abrogated by macrophage maturation with LPS of IFN-gamma. Using TREM-2(-/-) mice, we find that TREM-2 functions to inhibit cytokine production by macrophages in response to the TLR ligands LPS, zymosan, and CpG. Furthermore, we find that TREM-2 completely accounts for the increased cytokine production previously reported by DAP12(-/-) macrophages. Taken together, these data show that TREM-2 is expressed on newly differentiated and alternatively activated macrophages and functions to restrain macrophage activation.

Pubmed ID: 16951310


  • Turnbull IR
  • Gilfillan S
  • Cella M
  • Aoshi T
  • Miller M
  • Piccio L
  • Hernandez M
  • Colonna M


Journal of immunology (Baltimore, Md. : 1950)

Publication Data

September 15, 2006

Associated Grants

  • Agency: NIAID NIH HHS, Id: T32AI007163

Mesh Terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Cell Differentiation
  • Cell Movement
  • Humans
  • Inflammation Mediators
  • Jurkat Cells
  • Lung
  • Macrophage Activation
  • Macrophages, Peritoneal
  • Membrane Glycoproteins
  • Membrane Proteins
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Rats
  • Rats, Wistar
  • Receptors, Immunologic