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Sex differences in cortical thickness mapped in 176 healthy individuals between 7 and 87 years of age.

Findings from previous magnetic resonance imaging studies of sex differences in gray matter have been inconsistent, with some showing proportionally increased gray matter in women and some showing no differences between the sexes. Regional sex differences in gray matter thickness have not yet been mapped over the entire cortical surface in a large sample of subjects spanning the age range from early childhood to old age. We applied algorithms for cortical pattern matching and techniques for measuring cortical thickness to the structural magnetic resonance images of 176 healthy individuals between the ages of 7 and 87 years. We also mapped localized differences in brain size. Maps of sex differences in cortical thickness revealed thicker cortices in women in right inferior parietal and posterior temporal regions even without correcting for total brain volume. In these regions, the cortical mantle is up to 0.45 mm thicker, on average, in women than in men. Analysis of a subset of 18 female and 18 male subjects matched for age and brain volume confirmed the significance of thicker gray matter in temporal and parietal cortices in females, independent of brain size differences. Further analyses were conducted in the adult subjects where gender differences were evaluated using height as a covariate, and similar sex differences were observed even when body size differences between the sexes were controlled. Together, these results suggest that greater cortical thickness in posterior temporal inferior parietal regions in females relative to males are independent of differences in brain or body size. Age-by-sex interactions were not significant in the temporoparietal region, suggesting that sex differences in these regions are present from at least late childhood and then are maintained throughout life. Male brains were larger than female brains in all locations, though male enlargement was most prominent in the frontal and occipital poles, bilaterally. Given the large sample and the large range of ages studied, these results help to address controversies in the study of central nervous system sexual dimorphisms.

Pubmed ID: 16945978


  • Sowell ER
  • Peterson BS
  • Kan E
  • Woods RP
  • Yoshii J
  • Bansal R
  • Xu D
  • Zhu H
  • Thompson PM
  • Toga AW


Cerebral cortex (New York, N.Y. : 1991)

Publication Data

July 11, 2007

Associated Grants

  • Agency: NIA NIH HHS, Id: AG016570
  • Agency: NIBIB NIH HHS, Id: EB01651
  • Agency: NIMH NIH HHS, Id: K01 MH01733
  • Agency: NIMH NIH HHS, Id: K02 MH074677
  • Agency: NIMH NIH HHS, Id: K02 MH074677-03
  • Agency: NLM NIH HHS, Id: LM05639
  • Agency: NIMH NIH HHS, Id: MH068318
  • Agency: NIMH NIH HHS, Id: MH59139
  • Agency: PHS HHS, Id: MHK02-74677
  • Agency: NINDS NIH HHS, Id: NS3753
  • Agency: NCRR NIH HHS, Id: P41 RR013642
  • Agency: NIDA NIH HHS, Id: R01 017830DA
  • Agency: NIMH NIH HHS, Id: R01 MH068318
  • Agency: NIMH NIH HHS, Id: R01 MH068318-04
  • Agency: NIDA NIH HHS, Id: R21 DA015878
  • Agency: NCRR NIH HHS, Id: RR019771
  • Agency: NCRR NIH HHS, Id: U54 RR021813

Mesh Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Cerebral Cortex
  • Child
  • Female
  • Humans
  • Image Interpretation, Computer-Assisted
  • Imaging, Three-Dimensional
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Organ Size
  • Sex Factors