The Comparative Toxicogenomics Database (CTD): a resource for comparative toxicological studies.
The etiology of most chronic diseases involves interactions between environmental factors and genes that modulate important biological processes (Olden and Wilson, 2000. Nat Rev Genet 1(2):149-153). We are developing the publicly available Comparative Toxicogenomics Database (CTD) to promote understanding about the effects of environmental chemicals on human health. CTD identifies interactions between chemicals and genes and facilitates cross-species comparative studies of these genes. The use of diverse animal models and cross-species comparative sequence studies has been critical for understanding basic physiological mechanisms and gene and protein functions. Similarly, these approaches will be valuable for exploring the molecular mechanisms of action of environmental chemicals and the genetic basis of differential susceptibility.
Pubmed ID: 16902965
- Mattingly CJ
- Rosenstein MC
- Colby GT
- Forrest JN
- Boyer JL
Journal of experimental zoology. Part A, Comparative experimental biology
September 1, 2006
- Agency: NCRR NIH HHS, Id: P20 RR-016463
- Agency: NIEHS NIH HHS, Id: P30 ES003828
- Agency: NIEHS NIH HHS, Id: R01 ES014065
- Agency: NIEHS NIH HHS, Id: R33 ES011267
- Agency: NIEHS NIH HHS, Id: R33 ES11267
- Databases, Factual