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Dorsolateral prefrontal and anterior cingulate cortex volumetric abnormalities in adults with attention-deficit/hyperactivity disorder identified by magnetic resonance imaging.

OBJECTIVES: Gray and white matter volume deficits have been reported in a number of studies of children with attention-deficit/hyperactivity disorder (ADHD); however, there is a paucity of structural magnetic resonance imaging (MRI) studies of adults with ADHD. This structural MRI study used an a priori region of interest approach. METHODS: Twenty-four adults with DSM-IV ADHD and 18 healthy controls comparable on age, socioeconomic status, sex, handedness, education, IQ, and achievement test performance had an MRI on a 1.5T Siemens scanner. Cortical and sub-cortical gray and white matter were segmented. Image parcellation divided the neocortex into 48 gyral-based units per hemisphere. Based on a priori hypotheses we focused on prefrontal, anterior cingulate cortex (ACC) and overall gray matter volumes. General linear analyses of the volumes of brain regions, adjusting for age, sex, and total cerebral volumes, were used to compare groups. RESULTS: Relative to controls, ADHD adults had significantly smaller overall cortical gray matter, prefrontal and ACC volumes. CONCLUSIONS: Adults with ADHD have volume differences in brain regions in areas involved in attention and executive control. These data, largely consistent with studies of children, support the idea that adults with ADHD have a valid disorder with persistent biological features.

Pubmed ID: 16876137


  • Seidman LJ
  • Valera EM
  • Makris N
  • Monuteaux MC
  • Boriel DL
  • Kelkar K
  • Kennedy DN
  • Caviness VS
  • Bush G
  • Aleardi M
  • Faraone SV
  • Biederman J


Biological psychiatry

Publication Data

November 15, 2006

Associated Grants

  • Agency: NIMH NIH HHS, Id: F32 MH 065040-01A1
  • Agency: NIMH NIH HHS, Id: MH 16259
  • Agency: NIMH NIH HHS, Id: MH 57934
  • Agency: NICHD NIH HHS, Id: MH/HD 62152
  • Agency: NCRR NIH HHS, Id: P41 RR 14075

Mesh Terms

  • Adult
  • Attention Deficit Disorder with Hyperactivity
  • Brain Mapping
  • Female
  • Functional Laterality
  • Gyrus Cinguli
  • Humans
  • Imaging, Three-Dimensional
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Prefrontal Cortex