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Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice.

Science (New York, N.Y.) | Jul 28, 2006

Serotonin [5-hydroxytryptamine (5-HT)] neurotransmission in the central nervous system modulates depression and anxiety-related behaviors in humans and rodents, but the responsible downstream receptors remain poorly understood. We demonstrate that global disruption of 5-HT2A receptor (5HT2AR) signaling in mice reduces inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors. Selective restoration of 5HT2AR signaling to the cortex normalized conflict anxiety behaviors. These findings indicate a specific role for cortical 5HT2AR function in the modulation of conflict anxiety, consistent with models of cortical, "top-down" influences on risk assessment.

Pubmed ID: 16873667 RIS Download

Mesh terms: Animals | Anxiety | Cerebral Cortex | Conditioning (Psychology) | Conflict (Psychology) | Depression | Exploratory Behavior | Fear | Limbic System | Mice | Mice, Knockout | Patch-Clamp Techniques | Periaqueductal Gray | Prosencephalon | Receptor, Serotonin, 5-HT2A | Receptor, Serotonin, 5-HT2C | Receptors, Neurotransmitter | Risk-Taking | Serotonin | Signal Transduction | Synaptic Transmission

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Associated grants

  • Agency: NIMH NIH HHS, Id: KO8 MH01711
  • Agency: NIDA NIH HHS, Id: P01 DA12923

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