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Characterization of mice with targeted deletion of glycine receptor alpha 2.

Glycine receptors are ligand-gated chloride channels that mediate inhibitory neurotransmission in the adult nervous system. During development, glycine receptor alpha 2 (GlyRalpha2) is expressed in the retina, in the spinal cord, and throughout the brain. Within the cortex, GlyRalpha2 is expressed in immature cells and these receptors have been shown to be active and excitatory. In the developing retina, inhibition of glycine receptor activity prevents proper rod photoreceptor development. These data suggest that GlyRalpha2, the developmentally expressed glycine receptor, may play an important role in neuronal development. We have generated mice with a targeted deletion of glycine receptor alpha 2 (Glra2). Although these mice lack expression of GlyRalpha2, no gross morphological or molecular alterations were observed in the nervous system. In addition, the cerebral cortex does not appear to require glycine receptor activity for proper development, as Glra2 knockout mice did not show any electrophysiological responses to glycine.

Pubmed ID: 16847326

Authors

  • Young-Pearse TL
  • Ivic L
  • Kriegstein AR
  • Cepko CL

Journal

Molecular and cellular biology

Publication Data

August 18, 2006

Associated Grants

  • Agency: NICHD NIH HHS, Id: P30-HD 18655
  • Agency: NEI NIH HHS, Id: R01EY009676

Mesh Terms

  • Animals
  • Calcium
  • Cerebral Cortex
  • Female
  • Gene Deletion
  • Glycine
  • In Vitro Techniques
  • Mice
  • Mice, Knockout
  • Patch-Clamp Techniques
  • Pregnancy
  • Receptors, Glycine
  • Retina
  • Spinal Cord
  • Taurine