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Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family.

FEBS letters | Jul 24, 2006

By DNA cloning, we have identified the BSRP (brain-specific receptor-like proteins) family of three members in mammalian genomes. BSRPs were predominantly expressed in the soma and dendrites of neurons and localized in the endoplasmic reticulum (ER). Expression levels of BSRPs seemed to fluctuate greatly during postnatal cerebellar maturation. Triple-knockout mice lacking BSRP members exhibited motor discoordination, and Purkinje cells (PCs) were often innervated by multiple climbing fibers with different neuronal origins in the mutant cerebellum. Moreover, the phosphorylation levels of protein kinase Calpha (PKCalpha) were significantly downregulated in the mutant cerebellum. Because cerebellar maturation and plasticity require metabotropic glutamate receptor signaling and resulting PKC activation, BSRPs are likely involved in ER functions supporting PKCalpha activation in PCs.

Pubmed ID: 16814779 RIS Download

Mesh terms: Animals | Cerebellum | Dendrites | Down-Regulation | Enzyme Activation | Genome | Mice | Mice, Knockout | Mice, Neurologic Mutants | Multigene Family | Nerve Tissue Proteins | Phosphorylation | Protein Kinase C-alpha | Protein Processing, Post-Translational | Psychomotor Performance | Purkinje Cells | Receptors, Glutamate | Signal Transduction | Synapses

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Associated grants


Gene Ontology (Data, Gene Annotation)

Mouse Genome Informatics (Data, Gene Annotation)

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