We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.

Nature immunology | Jun 22, 2006

Recognition of double-stranded RNA activates interferon-regulatory factor 3 (IRF3)-dependent expression of antiviral factors. Although the molecular mechanisms underlying the activation of IRF3 have been studied, the mechanisms by which IRF3 activity is reduced have not. Here we report that activation of IRF3 is negatively regulated by the peptidyl-prolyl isomerase Pin1. After stimulation by double-stranded RNA, induced phosphorylation of the Ser339-Pro340 motif of IRF3 led to its interaction with Pin1 and finally polyubiquitination and then proteasome-dependent degradation of IRF3. Suppression of Pin1 by RNA interference or genetic deletion resulted in enhanced IRF-3-dependent production of interferon-beta, with consequent reduction of virus replication. These results elucidate a previously unknown mechanism for controlling innate antiviral responses by negatively regulating IRF3 activity via Pin1.

Pubmed ID: 16699525 RIS Download

Mesh terms: Animals | Cells, Cultured | DEAD Box Protein 58 | DEAD-box RNA Helicases | Down-Regulation | Immunity, Innate | Interferon Regulatory Factor-3 | Interferon-beta | Mice | Mice, Inbred Strains | NIMA-Interacting Peptidylprolyl Isomerase | Peptidylprolyl Isomerase | Phosphorylation | Proline | Proteasome Endopeptidase Complex | RNA Helicases | RNA Interference | RNA Virus Infections | RNA Viruses | RNA, Double-Stranded | Serine | Toll-Like Receptor 3 | Transcriptional Activation | Ubiquitin

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.