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Individual differences in reward drive predict neural responses to images of food.


A network of interconnected brain regions, including orbitofrontal, ventral striatal, amygdala, and midbrain areas, has been widely implicated in a number of aspects of food reward. However, in humans, sensitivity to reward can vary significantly from one person to the next. Individuals high in this trait experience more frequent and intense food cravings and are more likely to be overweight or develop eating disorders associated with excessive food intake. Using functional magnetic resonance imaging, we report that individual variation in trait reward sensitivity (as measured by the Behavioral Activation Scale) is highly correlated with activation to images of appetizing foods (e.g., chocolate cake, pizza) in a fronto-striatal-amygdala-midbrain network. Our findings demonstrate that there is considerable personality-linked variability in the neural response to food cues in healthy participants and provide important insight into the neurobiological factors underlying vulnerability to certain eating problems (e.g., hyperphagic obesity).

Pubmed ID: 16687507


  • Beaver JD
  • Lawrence AD
  • van Ditzhuijzen J
  • Davis MH
  • Woods A
  • Calder AJ


The Journal of neuroscience : the official journal of the Society for Neuroscience

Publication Data

May 10, 2006

Associated Grants

  • Agency: Medical Research Council, Id: G0001237
  • Agency: Medical Research Council, Id: G9439390
  • Agency: Medical Research Council, Id: MC_U105579214
  • Agency: Medical Research Council, Id: MC_U105580446

Mesh Terms

  • Adult
  • Brain
  • Cues
  • Evoked Potentials, Visual
  • Female
  • Food
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Nerve Net
  • Reward
  • Visual Perception