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Pannexin 1 in erythrocytes: function without a gap.

Proceedings of the National Academy of Sciences of the United States of America | 2006

ATP is a widely used extracellular signaling molecule. The mechanism of ATP release from cells is presently unresolved and may be either vesicular or channel-mediated. Erythrocytes release ATP in response to low oxygen or to shear stress. In the absence of vesicles, the release has to be through channels. Erythrocytes do not form gap junctions. Yet, here we show with immunohistochemical and electrophysiological data that erythrocytes express the gap junction protein pannexin 1. This protein, in addition to forming gap junction channels in paired oocytes, can also form a mechanosensitive and ATP-permeable channel in the nonjunctional plasma membrane. Consistent with a role of pannexin 1 as an ATP release channel, ATP release by erythrocytes was attenuated by the gap junction blocker carbenoxolone. Furthermore, under conditions of ATP release, erythrocytes took up fluorescent tracer molecules permeant to gap junction channels.

Pubmed ID: 16682648 RIS Download

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Associated grants

  • Agency: NIGMS NIH HHS, United States
    Id: R01 GM048610
  • Agency: NIGMS NIH HHS, United States
    Id: GM48610

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Chicken 4515 anti Pannexin1 (antibody)

RRID:AB_10013321

This polyclonal targets Panx1

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