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A functional network involved in the recycling of nucleocytoplasmic pre-60S factors.

Eukaryotic pre-ribosomes go through cytoplasmic maturation steps before entering translation. The nucleocytoplasmic proteins participating in these late stages of maturation are reimported to the nucleus. In this study, we describe a functional network focused on Rei1/Ybr267w, a strictly cytoplasmic pre-60S factor indirectly involved in nuclear 27S pre-ribosomal RNA processing. In the absence of Rei1, the nuclear import of at least three other pre-60S factors is impaired. The accumulation in the cytoplasm of a small complex formed by the association of Arx1 with a novel factor, Alb1/Yjl122w, inhibits the release of the putative antiassociation factor Tif6 from the premature large ribosomal subunits and its recycling to the nucleus. We propose a model in which Rei1 is a key factor for the coordinated dissociation and recycling of the last pre-60S factors before newly synthesized large ribosomal subunits enter translation.

Pubmed ID: 16651379


  • Lebreton A
  • Saveanu C
  • Decourty L
  • Rain JC
  • Jacquier A
  • Fromont-Racine M


The Journal of cell biology

Publication Data

May 8, 2006

Associated Grants


Mesh Terms

  • Active Transport, Cell Nucleus
  • Carrier Proteins
  • Cell Nucleus
  • Intermediate Filament Proteins
  • Membrane Transport Proteins
  • Models, Biological
  • Mutation
  • Phosphoproteins
  • Polyribosomes
  • Protein Binding
  • RNA-Binding Proteins
  • Receptors, Cytoplasmic and Nuclear
  • Ribosomal Proteins
  • Ribosomes
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Two-Hybrid System Techniques