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When the brain loses its self: prefrontal inactivation during sensorimotor processing.

A common theme in theories of subjective awareness poses a self-related "observer" function, or a homunculus, as a critical element without which awareness can not emerge. Here, we examined this question using fMRI. In our study, we compared brain activity patterns produced by a demanding sensory categorization paradigm to those engaged during self-reflective introspection, using similar sensory stimuli. Our results show a complete segregation between the two patterns of activity. Furthermore, regions that showed enhanced activity during introspection underwent a robust inhibition during the demanding perceptual task. The results support the notion that self-related processes are not necessarily engaged during sensory perception and can be actually suppressed.

Pubmed ID: 16630842


  • Goldberg II
  • Harel M
  • Malach R



Publication Data

April 20, 2006

Associated Grants


Mesh Terms

  • Acoustic Stimulation
  • Adult
  • Brain Mapping
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Photic Stimulation
  • Prefrontal Cortex
  • Self Concept