FlyTF: a systematic review of site-specific transcription factors in the fruit fly Drosophila melanogaster.
SUMMARY: We present a manually annotated catalogue of site-specific transcription factors (TFs) in the fruit fly Drosophila melanogaster. These were identified from a list of candidate proteins with transcription-related Gene Ontology (Go) annotation as well as structural DNA-binding domain assignments. For all 1052 candidate proteins, a defined set of rules was applied to classify information from the literature and computational data sources with respect to both DNA-binding and transcriptional regulatory properties. We propose a set of 753 TFs in the fruit fly, of which 23 are confident novel predictions of this function for previously uncharacterized proteins.
Pubmed ID: 16613907
Bioinformatics (Oxford, England)
June 15, 2006
- Agency: Medical Research Council, Id: MC_U105161047
- Computational Biology
- DNA-Binding Proteins
- Data Interpretation, Statistical
- Drosophila Proteins
- Drosophila melanogaster
- Protein Structure, Tertiary
- Transcription Factors
- Transcription, Genetic