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FlyTF: a systematic review of site-specific transcription factors in the fruit fly Drosophila melanogaster.

SUMMARY: We present a manually annotated catalogue of site-specific transcription factors (TFs) in the fruit fly Drosophila melanogaster. These were identified from a list of candidate proteins with transcription-related Gene Ontology (Go) annotation as well as structural DNA-binding domain assignments. For all 1052 candidate proteins, a defined set of rules was applied to classify information from the literature and computational data sources with respect to both DNA-binding and transcriptional regulatory properties. We propose a set of 753 TFs in the fruit fly, of which 23 are confident novel predictions of this function for previously uncharacterized proteins.

Pubmed ID: 16613907 RIS Download

Mesh terms: Animals | Computational Biology | DNA | DNA-Binding Proteins | Data Interpretation, Statistical | Drosophila Proteins | Drosophila melanogaster | Protein Structure, Tertiary | Software | Transcription Factors | Transcription, Genetic