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FlyTF: a systematic review of site-specific transcription factors in the fruit fly Drosophila melanogaster.

SUMMARY: We present a manually annotated catalogue of site-specific transcription factors (TFs) in the fruit fly Drosophila melanogaster. These were identified from a list of candidate proteins with transcription-related Gene Ontology (Go) annotation as well as structural DNA-binding domain assignments. For all 1052 candidate proteins, a defined set of rules was applied to classify information from the literature and computational data sources with respect to both DNA-binding and transcriptional regulatory properties. We propose a set of 753 TFs in the fruit fly, of which 23 are confident novel predictions of this function for previously uncharacterized proteins.

Pubmed ID: 16613907

Authors

  • Adryan B
  • Teichmann SA

Journal

Bioinformatics (Oxford, England)

Publication Data

June 15, 2006

Associated Grants

  • Agency: Medical Research Council, Id: MC_U105161047

Mesh Terms

  • Animals
  • Computational Biology
  • DNA
  • DNA-Binding Proteins
  • Data Interpretation, Statistical
  • Drosophila Proteins
  • Drosophila melanogaster
  • Protein Structure, Tertiary
  • Software
  • Transcription Factors
  • Transcription, Genetic