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Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1.

Nature immunology | May 19, 2006

http://www.ncbi.nlm.nih.gov/pubmed/16565719

The elimination of viruses and tumors by natural killer cells is mediated by specific natural killer cell receptors. To study the in vivo function of a principal activating natural killer cell receptor, NCR1 (NKp46 in humans), we replaced the gene encoding this receptor (Ncr1) with a green fluorescent protein reporter cassette. There was enhanced spread of certain tumors in 129/Sv but not C57BL/6 Ncr1(gfp/gfp) mice, and influenza virus infection was lethal in both 129/Sv and C57BL/6 Ncr1(gfp/gfp) mice. We noted accumulation of natural killer cells at the site of influenza infection by tracking the green fluorescent protein. Our results demonstrate a critical function for Ncr1 in the in vivo eradication of influenza virus.

Pubmed ID: 16565719 RIS Download

Mesh terms: Animals | Cell Line | Green Fluorescent Proteins | Humans | Immunity, Innate | Influenza A virus | Killer Cells, Natural | Mice | Mice, Knockout | Natural Cytotoxicity Triggering Receptor 1 | Orthomyxoviridae Infections | Receptors, Immunologic | Species Specificity | Survival Rate

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