• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents.

TRPA1 is an excitatory ion channel targeted by pungent irritants from mustard and garlic. TRPA1 has been proposed to function in diverse sensory processes, including thermal (cold) nociception, hearing, and inflammatory pain. Using TRPA1-deficient mice, we now show that this channel is the sole target through which mustard oil and garlic activate primary afferent nociceptors to produce inflammatory pain. TRPA1 is also targeted by environmental irritants, such as acrolein, that account for toxic and inflammatory actions of tear gas, vehicle exhaust, and metabolic byproducts of chemotherapeutic agents. TRPA1-deficient mice display normal cold sensitivity and unimpaired auditory function, suggesting that this channel is not required for the initial detection of noxious cold or sound. However, TRPA1-deficient mice exhibit pronounced deficits in bradykinin-evoked nociceptor excitation and pain hypersensitivity. Thus, TRPA1 is an important component of the transduction machinery through which environmental irritants and endogenous proalgesic agents depolarize nociceptors to elicit inflammatory pain.

Pubmed ID: 16564016

Authors

  • Bautista DM
  • Jordt SE
  • Nikai T
  • Tsuruda PR
  • Read AJ
  • Poblete J
  • Yamoah EN
  • Basbaum AI
  • Julius D

Journal

Cell

Publication Data

March 24, 2006

Associated Grants

None

Mesh Terms

  • Acrolein
  • Animals
  • Cold Temperature
  • Evoked Potentials, Auditory, Brain Stem
  • Garlic
  • Inflammation
  • Inhalation Exposure
  • Mice
  • Mice, Knockout
  • Molecular Structure
  • Nociceptors
  • Pain
  • Thermoreceptors
  • Transient Receptor Potential Channels