• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions.

Nup98 and Nup96 are components of the nuclear transport machinery and are induced by interferons (IFN). Nup98 is a constituent of an mRNA export pathway that is targeted by viruses and regulated by IFN. However, the role of Nup96 in IFN-related mechanisms has not been established. To investigate the function of Nup96 in vivo, we generated Nup96(+/-) mice that express low levels of Nup96, as Nup96(-/-) mice are lethal. The Nup96(+/-) mice presented selective alterations of the immune system, which resulted in downregulation and impaired IFN alpha- and gamma-mediated induction of MHC I and IFNgamma induction of MHC II, ICAM-1, and other proteins. Frequency of TCRalphabeta+ and CD4+ T cells, which depends on MHC function, is reduced in NUP96(+/-) mice. Upon immunization, Nup96(+/-) mice showed impaired antigen presentation and T cell proliferation. Nup96(+/-) cells and mice were highly susceptible to viral infection, demonstrating a role for Nup96 in innate and adaptive immunity.

Pubmed ID: 16546098


  • Faria AM
  • Levay A
  • Wang Y
  • Kamphorst AO
  • Rosa ML
  • Nussenzveig DR
  • Balkan W
  • Chook YM
  • Levy DE
  • Fontoura BM



Publication Data

March 20, 2006

Associated Grants

  • Agency: NIAID NIH HHS, Id: AI28900
  • Agency: NIGMS NIH HHS, Id: R01 GM067159-01

Mesh Terms

  • Animals
  • Antigens, CD86
  • B-Lymphocytes
  • Cell Nucleus
  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II
  • Immunity, Innate
  • Intercellular Adhesion Molecule-1
  • Interferon-gamma
  • Interleukin-4
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Nuclear Pore Complex Proteins
  • RNA, Messenger
  • T-Lymphocytes