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The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions.

Immunity | Mar 20, 2006

Nup98 and Nup96 are components of the nuclear transport machinery and are induced by interferons (IFN). Nup98 is a constituent of an mRNA export pathway that is targeted by viruses and regulated by IFN. However, the role of Nup96 in IFN-related mechanisms has not been established. To investigate the function of Nup96 in vivo, we generated Nup96(+/-) mice that express low levels of Nup96, as Nup96(-/-) mice are lethal. The Nup96(+/-) mice presented selective alterations of the immune system, which resulted in downregulation and impaired IFN alpha- and gamma-mediated induction of MHC I and IFNgamma induction of MHC II, ICAM-1, and other proteins. Frequency of TCRalphabeta+ and CD4+ T cells, which depends on MHC function, is reduced in NUP96(+/-) mice. Upon immunization, Nup96(+/-) mice showed impaired antigen presentation and T cell proliferation. Nup96(+/-) cells and mice were highly susceptible to viral infection, demonstrating a role for Nup96 in innate and adaptive immunity.

Pubmed ID: 16546098 RIS Download

Mesh terms: Animals | Antigens, CD86 | B-Lymphocytes | Cell Nucleus | Histocompatibility Antigens Class I | Histocompatibility Antigens Class II | Immunity, Innate | Intercellular Adhesion Molecule-1 | Interferon-gamma | Interleukin-4 | Mice | Mice, Inbred BALB C | Mice, Inbred C57BL | Mice, Knockout | Nuclear Pore Complex Proteins | RNA, Messenger | T-Lymphocytes

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Associated grants

  • Agency: NIAID NIH HHS, Id: AI28900
  • Agency: NIGMS NIH HHS, Id: R01 GM067159-01

Mouse Genome Informatics (Data, Gene Annotation)

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