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The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions.

Nup98 and Nup96 are components of the nuclear transport machinery and are induced by interferons (IFN). Nup98 is a constituent of an mRNA export pathway that is targeted by viruses and regulated by IFN. However, the role of Nup96 in IFN-related mechanisms has not been established. To investigate the function of Nup96 in vivo, we generated Nup96(+/-) mice that express low levels of Nup96, as Nup96(-/-) mice are lethal. The Nup96(+/-) mice presented selective alterations of the immune system, which resulted in downregulation and impaired IFN alpha- and gamma-mediated induction of MHC I and IFNgamma induction of MHC II, ICAM-1, and other proteins. Frequency of TCRalphabeta+ and CD4+ T cells, which depends on MHC function, is reduced in NUP96(+/-) mice. Upon immunization, Nup96(+/-) mice showed impaired antigen presentation and T cell proliferation. Nup96(+/-) cells and mice were highly susceptible to viral infection, demonstrating a role for Nup96 in innate and adaptive immunity.

Pubmed ID: 16546098


  • Faria AM
  • Levay A
  • Wang Y
  • Kamphorst AO
  • Rosa ML
  • Nussenzveig DR
  • Balkan W
  • Chook YM
  • Levy DE
  • Fontoura BM



Publication Data

March 20, 2006

Associated Grants

  • Agency: NIAID NIH HHS, Id: AI28900
  • Agency: NIGMS NIH HHS, Id: R01 GM067159-01

Mesh Terms

  • Animals
  • Antigens, CD86
  • B-Lymphocytes
  • Cell Nucleus
  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II
  • Immunity, Innate
  • Intercellular Adhesion Molecule-1
  • Interferon-gamma
  • Interleukin-4
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Nuclear Pore Complex Proteins
  • RNA, Messenger
  • T-Lymphocytes