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Brain systems mediating cognitive interference by emotional distraction.

Flexible behavior depends on our ability to cope with distracting stimuli that can interfere with the attainment of goals. Emotional distracters can be particularly disruptive to goal-oriented behavior, but the neural systems through which these detrimental effects are mediated are not known. We used event-related functional magnetic resonance imaging to investigate the effect of emotional and nonemotional distracters on a delayed-response working memory (WM) task. As expected, this task evoked robust activity during the delay period in typical WM regions (dorsolateral prefrontal cortex and lateral parietal cortex). Presentation of emotional distracters during the delay interval evoked strong activity in typical emotional processing regions (amygdala and ventrolateral prefrontal cortex) while simultaneously evoking relative deactivation of the WM regions and impairing WM performance. These results provide the first direct evidence that the detrimental effect of emotional distracters on ongoing cognitive processes entails the interaction between a dorsal neural system associated with "cold" executive processing and a ventral system associated with "hot" emotional processing.

Pubmed ID: 16481440

Authors

  • Dolcos F
  • McCarthy G

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience

Publication Data

February 15, 2006

Associated Grants

  • Agency: NINDS NIH HHS, Id: P01-NS41328
  • Agency: NIMH NIH HHS, Id: P50-MH60451
  • Agency: NIMH NIH HHS, Id: R01-MH05286

Mesh Terms

  • Adolescent
  • Adult
  • Brain
  • Cognition
  • Emotions
  • Face
  • Female
  • Functional Laterality
  • Humans
  • Male
  • Memory
  • Reaction Time