Our hosting provider will be performing UPS maintenance on Tuesday, Oct 25, 2016 between 8 AM and 5 PM PDT. SciCrunch searching services will be down during this time.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Training-induced functional activation changes in dual-task processing: an FMRI study.


Although training-induced changes in brain activity have been previously examined, plasticity associated with executive functions remains understudied. In this study, we examined training-related changes in cortical activity during a dual task requiring executive control. Two functional magnetic resonance imaging (fMRI) sessions, one before training and one after training, were performed on both a control group and a training group. Using a region-of-interest analysis, we examined Time x Group and Time x Group x Condition interactions to isolate training-dependent changes in activation. We found that most regions involved in dual-task processing before training showed reductions in activation after training. Many of the decreases in activation were correlated with improved performance on the task. We also found an area in the dorsolateral prefrontal cortex that showed an increase in activation for the training group for the dual-task condition, which was also correlated with improved performance. These results are discussed in relation to the efficacy of training protocols for modulating attention and executive functions, dual-task processing, and fMRI correlates of plasticity.

Pubmed ID: 16467562


  • Erickson KI
  • Colcombe SJ
  • Wadhwa R
  • Bherer L
  • Peterson MS
  • Scalf PE
  • Kim JS
  • Alvarado M
  • Kramer AF


Cerebral cortex (New York, N.Y. : 1991)

Publication Data

January 12, 2007

Associated Grants

  • Agency: NIA NIH HHS, Id: R01 AG025032
  • Agency: NIA NIH HHS, Id: R01 AG025667

Mesh Terms

  • Adult
  • Brain
  • Data Interpretation, Statistical
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Intelligence Tests
  • Learning
  • Magnetic Resonance Imaging
  • Male
  • Neuronal Plasticity
  • Psychomotor Performance
  • Reaction Time