Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

GFAP-positive progenitor cells produce neurons and oligodendrocytes throughout the CNS.

http://www.ncbi.nlm.nih.gov/pubmed/16458536

Once thought to merely act as scaffolds in neuronal migration, recent evidence suggests that radial glia may serve as progenitors for the majority of neurons in the CNS. Cre/loxP fate-mapping experiments were carried out using a fragment of a glial-specific promoter (glial fibrillary acidic protein; GFAP) to drive expression of Cre recombinase. We show that GFAP+ progenitor cells give rise to neurons and oligodendrocytes throughout the CNS. We find very little regional heterogeneity in the neurogenic potential of radial glia between dorsal and ventral telencephalon. Additionally, radial glia serve as precursors for subpopulations of interneurons in the ventral telencephalon. Interestingly, the human GFAP promoter but not the mouse GFAP promoter is active in oligodendrocyte progenitor cells. We also demonstrate that the most commonly used Cre reporter lines are very inefficient in detecting Cre-dependent recombination in astrocytes and describe a new Cre reporter line for assessing recombination in astrocytes.

Pubmed ID: 16458536 RIS Download

Mesh terms: Animals | Astrocytes | Cell Differentiation | Cell Lineage | Central Nervous System | Genes, Reporter | Glial Fibrillary Acidic Protein | Humans | Integrases | Mice | Mice, Transgenic | Neurons | Oligodendroglia | Promoter Regions, Genetic | Recombinant Fusion Proteins | Recombination, Genetic | Stem Cells

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.