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Immunosurveillance and immunoregulation by gammadelta T cells.

Whereas the vast majority of T cells express a T-cell receptor (TCR) composed of alphabeta heterodimers, a smaller population expresses a gammadelta TCR. In contrast to alphabeta T cells, gammadelta T cells show less TCR diversity, are particularly enriched at epithelial surfaces and appear to respond to self-molecules that signal potential danger or cellular stress. In addition, various subsets of gammadelta T cells have shown antitumor and immunoregulatory activities. This review considers what has been discovered about the important cutaneous functions of gammadelta T cells through the study of mutant mice and offers perspectives on the roles of gammadelta T cells in human disease.

Pubmed ID: 16417214


  • Girardi M


The Journal of investigative dermatology

Publication Data

January 18, 2006

Associated Grants


Mesh Terms

  • Animals
  • Bacterial Infections
  • Dendritic Cells
  • Epidermis
  • Humans
  • Immunologic Surveillance
  • Mice
  • Neoplasms
  • Receptors, Antigen, T-Cell, gamma-delta
  • T-Lymphocytes