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The PeptideAtlas project.

Nucleic acids research | Jan 1, 2006

http://www.ncbi.nlm.nih.gov/pubmed/16381952

The completion of the sequencing of the human genome and the concurrent, rapid development of high-throughput proteomic methods have resulted in an increasing need for automated approaches to archive proteomic data in a repository that enables the exchange of data among researchers and also accurate integration with genomic data. PeptideAtlas (http://www.peptideatlas.org/) addresses these needs by identifying peptides by tandem mass spectrometry (MS/MS), statistically validating those identifications and then mapping identified sequences to the genomes of eukaryotic organisms. A meaningful comparison of data across different experiments generated by different groups using different types of instruments is enabled by the implementation of a uniform analytic process. This uniform statistical validation ensures a consistent and high-quality set of peptide and protein identifications. The raw data from many diverse proteomic experiments are made available in the associated PeptideAtlas repository in several formats. Here we present a summary of our process and details about the Human, Drosophila and Yeast PeptideAtlas builds.

Pubmed ID: 16381952 RIS Download

Mesh terms: Animals | Chromosome Mapping | Databases, Protein | Drosophila Proteins | Humans | Internet | Mass Spectrometry | Peptide Fragments | Proteome | Proteomics | Saccharomyces cerevisiae Proteins | Sequence Analysis, Protein | User-Computer Interface